Pith Number

pith:KX32BWIL

pith:2026:KX32BWIL64SXNYTNXHH2DF6LHS

not attested not anchored not stored refs resolved

An exponential logarithmic measure of drug receptor binding and saturation

Arturo Tozzi

Exponential logarithmic descriptor integrates binding affinity and concentration to reveal wider dynamic range in receptor saturation.

arxiv:2605.16466 v1 · 2026-05-15 · q-bio.OT

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\usepackage{pith}
\pithnumber{KX32BWIL64SXNYTNXHH2DF6LHS}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

Compared with conventional occupancy curves, ELD retained a broader dynamic range and revealed asymmetric sensitivity across concentration scales, particularly at low exposure and near saturation, where bounded occupancy measures progressively compress variability.

C2weakest assumption

That the specific combination of logarithmic free-energy term and inverse normalized exponential concentration term accurately represents the coexistence of amplification and constraint processes in ligand-receptor dynamics, as this is asserted without derivation details or experimental confirmation in the abstract.

C3one line summary

Proposes a new exponential-logarithmic descriptor (ELD) for drug-receptor interactions that integrates thermodynamic and probabilistic aspects and exhibits broader dynamic range in numerical simulations.

References

22 extracted · 22 resolved · 1 Pith anchors

[1] A Free -Energy Landscape for the Glucagon -Like Peptide 1 Receptor GLP1R 2020 · doi:10.1002/prot.25777

[2] Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations 2024 · doi:10.1021/acs.jpcb.4c05732

[3] Activation/Deactivation Free-Energy Profiles for the β2-Adrenergic Receptor: Ligand Modes of Action 2023 · doi:10.1021/acs.jcim.3c00805

[4] Polymeric Immunoglobulin Receptor (pIgR) in Cancer 2023 · doi:10.1007/s00432-023-05335-4

[5] Comparison of Receptor -Ligand Restraint Schemes for Alchemical Absolute Binding Free Energy Calculations 2023 · doi:10.1021/acs.jctc.3c00139

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-20T00:02:23.454788Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

55f7a0d90bf72576e26db9cfa197cb3c9dfe945c78343e8367550c45959c4463

Aliases

arxiv: 2605.16466 · arxiv_version: 2605.16466v1 · doi: 10.48550/arxiv.2605.16466 · pith_short_12: KX32BWIL64SX · pith_short_16: KX32BWIL64SXNYTN · pith_short_8: KX32BWIL

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/KX32BWIL64SXNYTNXHH2DF6LHS \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 55f7a0d90bf72576e26db9cfa197cb3c9dfe945c78343e8367550c45959c4463

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "fbe31d245f80c7fcabf8a9715195eb767814fc2be7027fabb741d6421a9af1af",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "q-bio.OT",
    "submitted_at": "2026-05-15T10:47:14Z",
    "title_canon_sha256": "0672b2604d7159c4156772f2b551abfe358a05914135ef870bba39f24c291671"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.16466",
    "kind": "arxiv",
    "version": 1
  }
}