Pith Number

pith:MEDU4U2W

pith:2026:MEDU4U2WGBFVWSYCARTZAELJE2

not attested not anchored not stored refs resolved

Modeling tumor cell heterogeneity and plasticity in adaptive therapy

Chenghang Li, Jinzhi Lei, Rui Yue

A mathematical model with continuous drug susceptibility shows adaptive therapy controls tumors longer than fixed dosing by regulating sensitive cell populations.

arxiv:2605.17208 v1 · 2026-05-17 · q-bio.PE

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\usepackage{pith}
\pithnumber{MEDU4U2WGBFVWSYCARTZAELJE2}

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Record completeness

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2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

Analytical and numerical studies show that (i) continuous therapy drives rapid expansion of resistant clones, (ii) adaptive therapy maintains long-term tumor control by dynamically regulating sensitive populations, and (iii) high phenotypic plasticity accelerates phenotype switching, leading to earlier tumor relapse following continuous therapy.

C2weakest assumption

The probabilistic inheritance function and continuous drug susceptibility index are assumed to sufficiently represent real biological plasticity and heterogeneity in tumor cells, as stated in the model proposal without reference to specific empirical calibration or validation data.

C3one line summary

An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.

References

34 extracted · 34 resolved · 0 Pith anchors

[1] Siegel, Mathieu Laversanne, Isabelle Soerjo- mataram, Ahmedin Jemal, and Freddie Bray 2020

[2] Mel Greaves and Carlo C. Maley. Clonal evolution in cancer.Nature, 481(7381):306–313, January 2012 2012

[3] Robert A. Gatenby, Ariosto S. Silva, Robert J. Gillies, and B. Roy Frieden. Adaptive therapy.Cancer Res, 69(11):4894–4903, June 2009 2009

[4] Gatenby and Joel S 2020

[5] Athena Aktipis and Randolph M 2013

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-20T00:03:45.277809Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

61074e5356304b5b4b020467901169269e37a446be7268b81f2c4fe8373dee33

Aliases

arxiv: 2605.17208 · arxiv_version: 2605.17208v1 · doi: 10.48550/arxiv.2605.17208 · pith_short_12: MEDU4U2WGBFV · pith_short_16: MEDU4U2WGBFVWSYC · pith_short_8: MEDU4U2W

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/MEDU4U2WGBFVWSYCARTZAELJE2 \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 61074e5356304b5b4b020467901169269e37a446be7268b81f2c4fe8373dee33

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "9ca9d4b6571dcbc2b09d9f560c35552c6bac3e4b2952fd267aef0db813321fdb",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
    "primary_cat": "q-bio.PE",
    "submitted_at": "2026-05-17T00:50:01Z",
    "title_canon_sha256": "55c5315d506d8628df8a78d7466bee2c5f0cdfbb058626b602485aed725a0f0b"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.17208",
    "kind": "arxiv",
    "version": 1
  }
}