Pith Number

pith:N4MHRPDQ

pith:2026:N4MHRPDQCSOROMRQBAZABXLFWT

not attested not anchored not stored refs resolved

A senescent-immune reserve niche model for incomplete lobular involution in the aging breast

Amy C. Degnim, Darren J. Baker, Derek C. Radisky, Jaida C. Lue, Mark E. Sherman, Stacey J. Winham

Persistent breast lobules after menopause are actively maintained by a senescent-immune reserve niche.

arxiv:2605.13902 v1 · 2026-05-12 · q-bio.TO

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\usepackage{pith}
\pithnumber{N4MHRPDQCSOROMRQBAZABXLFWT}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

Persistent lobules are maintained by an active reserve niche that outlasts its reproductive function, created when impaired immune surveillance allows inflammatory paracrine signaling, macrophage reprogramming, and immune evasion to form a self-sustaining senescent-immune niche lock.

C2weakest assumption

That the integration of existing epidemiology, stromal biology, senescence, and immune surveillance literature is sufficient to establish menopause as a control point where tissue fate diverges specifically via senescent-immune interactions, rather than other unmodeled factors.

C3one line summary

Persistent breast lobules after menopause are maintained by an active senescent-immune niche that impairs clearance and sustains inflammation, explaining their link to elevated cancer risk.

References

10 extracted · 10 resolved · 0 Pith anchors

[1] Increased systemic inflammation and altered distribution of T -cell subsets in postmenopausal women 2020

[2] Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 1999

[3] Lancet 360(9328): 187-195. Cousins, F. L., C. E. Filby and C. E. Gargett (2021) 2002

[4] Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity 2023

[5] Association between local inflammation and breast tissue age- related lobular involution among premenopausal and postmenopausal breast cancer patients 2017

Formal links

1 machine-checked theorem link

Receipt and verification

First computed	2026-05-17T23:39:18.919115Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

6f1878bc70149d173230083200dd65b4cbcdaf52ccf749e366fc5d8534201e2c

Aliases

arxiv: 2605.13902 · arxiv_version: 2605.13902v1 · doi: 10.48550/arxiv.2605.13902 · pith_short_12: N4MHRPDQCSOR · pith_short_16: N4MHRPDQCSOROMRQ · pith_short_8: N4MHRPDQ

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/N4MHRPDQCSOROMRQBAZABXLFWT \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 6f1878bc70149d173230083200dd65b4cbcdaf52ccf749e366fc5d8534201e2c

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "c414b70fd07d7b803bc07609947e9b4a0e3c738543e2b3a187994d3cdb536658",
    "cross_cats_sorted": [],
    "license": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
    "primary_cat": "q-bio.TO",
    "submitted_at": "2026-05-12T21:39:11Z",
    "title_canon_sha256": "0a811d5119f16225c31e817d21eac73340e953139e05b28e9226303193bcef08"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.13902",
    "kind": "arxiv",
    "version": 1
  }
}