Pith Number

pith:PUKUXJX2

pith:2026:PUKUXJX2LPYAJJD2ZZHCV2CEA2

not attested not anchored not stored refs pending

Development of a Proton Therapy Research Beamline with FLASH and Minibeam Capabilities at the 18 MeV Bern Medical Cyclotron

Alexander Gottstein, Cristian Fernandez Palomo, Eva Kasanda, Gaia Dellepiane, Isidre Mateu, Jan Gruber, Lars Eggiman, Maria Vittoria Rossi, Paola Scampoli, Paolo Pellicioli, Pierluigi Casolaro, Saverio Braccini, Thierry Stammbach

The 18 MeV Bern Medical Cyclotron beamline has been adapted to deliver protons across conventional to FLASH dose rates and minibeam patterns for pre-clinical radiobiology.

arxiv:2605.05441 v2 · 2026-05-06 · physics.med-ph · physics.acc-ph · physics.ins-det

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\pithnumber{PUKUXJX2LPYAJJD2ZZHCV2CEA2}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

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The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

The adapted BMC provides a flexible and accessible platform for systematic pre-clinical proton radiobiology studies under varied dose-rate and spatial delivery conditions. This supports optimization of emerging modalities such as proton FLASH and SFRT and helps bridge accelerator technology and radiobiology.

C2weakest assumption

That the implemented dosimetric framework with LET-dependent corrections on radiochromic film enables quantitative and accurate dose delivery measurements in in-vitro setups, and that the reported beam uniformity and stability are adequate for reliable radiobiology experiments.

C3one line summary

The 18 MeV Bern Medical Cyclotron beamline was modified with collimators, scattering foils, and dosimetry tools to deliver stable proton beams at dose rates from 0.01 to 100 Gy/s with under 8% uniformity, supporting FLASH and minibeam research.

Receipt and verification

First computed	2026-05-21T01:05:20.254920Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

7d154ba6fa5bf004a47ace4e2ae84406a0f220f07eb308de30edbdc0205d138b

Aliases

arxiv: 2605.05441 · arxiv_version: 2605.05441v2 · doi: 10.48550/arxiv.2605.05441 · pith_short_12: PUKUXJX2LPYA · pith_short_16: PUKUXJX2LPYAJJD2 · pith_short_8: PUKUXJX2

Agent API

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Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/PUKUXJX2LPYAJJD2ZZHCV2CEA2 \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 7d154ba6fa5bf004a47ace4e2ae84406a0f220f07eb308de30edbdc0205d138b

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "02631b7e6a18b91630eeef7413e15728a8c515fd168f1026abac87861352091e",
    "cross_cats_sorted": [
      "physics.acc-ph",
      "physics.ins-det"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "physics.med-ph",
    "submitted_at": "2026-05-06T20:57:29Z",
    "title_canon_sha256": "4e9b0a876a0e4a3a07a6b9e08412a8a89b5da317bb715861560c4686143bb004"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.05441",
    "kind": "arxiv",
    "version": 2
  }
}