Pith Number

pith:SNTL7X6Y

pith:2026:SNTL7X6YHXHFEI232BQJM7V36B

not attested not anchored not stored refs resolved

Voxel-aware oxygen kinetics resolves radiation-induced DNA damage retention across LET-oxygen conditions

Ramon Jose C. Bagunu, Renato III Fernan Bolo

Voxel-aware oxygen kinetics enables particle-specific modeling of DNA damage retention across LET and oxygen conditions at clinical planning speeds.

arxiv:2605.12558 v2 · 2026-05-11 · physics.med-ph

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\usepackage{pith}
\pithnumber{SNTL7X6YHXHFEI232BQJM7V36B}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

VOxA is the first particle-specific OER model to reproduce Z-ordering analytically at clinical planning speed, validated on the largest OER calibration dataset for this model class.

C2weakest assumption

The dual sigmoidal LET-OER transitions constrained to increase monotonically with atomic number Z, combined with Michaelis-Menten kinetics and a single calibrated particle-specific sensitivity parameter, sufficiently capture the underlying biology across the full range of LET and oxygen conditions.

C3one line summary

VOxA achieves R²=0.719 on 233 OER observations across 10 particle types and outperforms clinical standards by 28.4% in survival OER MAE while running over 10^6 times faster than Monte Carlo.

References

60 extracted · 60 resolved · 0 Pith anchors

[1] Alper, T. and Howard-Flanders, P. , title =. Nature , year =

[2] Arnould, C. and Rocher, V. and Finoux, A.-L. and others , title =. Nature , year =

[3] and Paganetti, Harald and Schuemann, Jan , title =

[4] Cancers , year =

[5] D-Kondo, Naoki and Masilela, Thongchai A. M. and Shin, Wook-Geun and Faddegon, Bruce and LaVerne, Jay and Schuemann, Jan and Ramos-Mendez, Jose , title =. Physics in Medicine and Biology , year =. doi · doi:10.1088/1361-6560/ad87a7

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-18T03:10:02.020485Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

9366bfdfd83dce52235bd060967ebbf0537162e732c22299a34ef65ec9ca4928

Aliases

arxiv: 2605.12558 · arxiv_version: 2605.12558v2 · doi: 10.48550/arxiv.2605.12558 · pith_short_12: SNTL7X6YHXHF · pith_short_16: SNTL7X6YHXHFEI23 · pith_short_8: SNTL7X6Y

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/SNTL7X6YHXHFEI232BQJM7V36B \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 9366bfdfd83dce52235bd060967ebbf0537162e732c22299a34ef65ec9ca4928

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "5049b1e906de427361059f6a7a3a5055739b9d9270e3de294eb1f695c6ffd5cd",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by-nc-sa/4.0/",
    "primary_cat": "physics.med-ph",
    "submitted_at": "2026-05-11T15:00:31Z",
    "title_canon_sha256": "ba9c369effd5745549160cb6454c56450c30e55568ac27fc9679902fdb08ee3b"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.12558",
    "kind": "arxiv",
    "version": 2
  }
}