Pith Number

pith:TDAFOU7Z

pith:2026:TDAFOU7ZDTOUMUVKDXFXPRWIFD

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Novel Chemical Pathways for the Formation of Nucleobase Precursors via Benzene {\pi}-Bond Addition to HCN

Danica J. Adams, Jeehyun Yang, Renyu Hu, Yuk L. Yung

Benzene reacts with HCN through 1,4-cycloaddition and fragmentation to form pyrimidine precursors for nucleobases.

arxiv:2605.00035 v1 · 2026-04-28 · physics.chem-ph · astro-ph.EP

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\pithnumber{TDAFOU7ZDTOUMUVKDXFXPRWIFD}

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2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

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The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

We propose that nitrogen incorporation occurred through HCN 1,4-cycloaddition to benzene's π-system, followed by a C2H2 fragmentation mechanism, as confirmed by quantum chemistry calculations. This pathway... can lead to pyrimidine formation, which can further react with NH3 and HCN to produce purine.

C2weakest assumption

That benzene accumulates in sufficient quantities on early Earth or Mars and that the proposed cycloaddition and fragmentation steps occur at rates competitive with other loss processes under the modeled conditions.

C3one line summary

Benzene reacts with HCN via 1,4-cycloaddition and C2H2 loss to yield pyrimidine, which then forms purine with NH3 and HCN, as shown by quantum calculations and modeled for cold dry Mars conditions.

References

17 extracted · 6 resolved · 0 Pith anchors

[1] Automatic estimation of pressure-dependent rate coefficients. Phys. Chem. Chem. Phys. 14, 1131–

[2] Allen, M., Yung, Y .L., Waters, J.W 1981 · doi:10.1039/c1cp22765c

[3] The Journal of chemical physics 152 1970

[4] S., & Smolarkiewicz, P 2020 · doi:10.1175/1520-

[5] The Astrophysical journal letters 891, L41 2003 · doi:10.1016/s0019-1035(02)00028-3

Receipt and verification

First computed	2026-05-20T00:00:40.102573Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

98c05753f91cdd4652aa1dcb77c6c828ca96a6a56e0b0a39022ce82b0d2b5a6d

Aliases

arxiv: 2605.00035 · arxiv_version: 2605.00035v1 · doi: 10.48550/arxiv.2605.00035 · pith_short_12: TDAFOU7ZDTOU · pith_short_16: TDAFOU7ZDTOUMUVK · pith_short_8: TDAFOU7Z

Agent API

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Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/TDAFOU7ZDTOUMUVKDXFXPRWIFD \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 98c05753f91cdd4652aa1dcb77c6c828ca96a6a56e0b0a39022ce82b0d2b5a6d

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "fde94f062b1f951c74595ed33c7a6126e529a286aef3707b255052a2d817ce6e",
    "cross_cats_sorted": [
      "astro-ph.EP"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "physics.chem-ph",
    "submitted_at": "2026-04-28T06:08:37Z",
    "title_canon_sha256": "d4fb4230d70fbe5d7f3d2b74a612563bfa669a05e07f7adfb19e91b8c858b84a"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.00035",
    "kind": "arxiv",
    "version": 1
  }
}