pith:VXYNKCEW
Non-monotonic variation with salt concentration of the second virial coefficient in protein solutions
Discrete charges on a protein surface produce a non-monotonic second virial coefficient that first falls, then rises, then falls again with added salt.
arxiv:cond-mat/0205551 v1 · 2002-05-27 · cond-mat.soft · cond-mat.stat-mech · q-bio
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Record completeness
Claims
For parameters roughly corresponding to lysozyme, B2 first decreases with added salt up to a threshold concentration, then increases to a maximum, and then decreases again upon further raising the ionic strength.
The primitive-model representation with a fixed discrete charge pattern on a spherical protein of lysozyme size and charge density is sufficient to capture the dominant physics governing B2 at the salt concentrations examined.
Primitive-model simulations with discrete protein charges produce a non-monotonic B2 versus added salt that DLVO theory misses.
Formal links
Receipt and verification
| First computed | 2026-07-04T16:32:17.792435Z |
|---|---|
| Builder | pith-number-builder-2026-05-17-v1 |
| Signature | Pith Ed25519
(pith-v1-2026-05) · public key |
| Schema | pith-number/v1.0 |
Canonical hash
adf0d50896df94f6c8b5c484cd4ff5a17f00f5185b3f300de138b888ea417ac5
Aliases
· · · · ·Agent API
Verify this Pith Number yourself
curl -sH 'Accept: application/ld+json' https://pith.science/pith/VXYNKCEW36KPNSFVYSCM2T7VUF \
| jq -c '.canonical_record' \
| python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: adf0d50896df94f6c8b5c484cd4ff5a17f00f5185b3f300de138b888ea417ac5
Canonical record JSON
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