Pith Number

pith:WC25VHXO

pith:2026:WC25VHXO2UJZSSQTFG7O2LAVSN

not attested not anchored not stored refs resolved

Control Laws in Aging and Longevity

Alex Zhavoronkov

Aging is the rising cost of safely steering biology back to healthy states, and lowering this cost ranks interventions by translational success.

arxiv:2605.16781 v1 · 2026-05-16 · q-bio.MN · q-bio.PE

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\usepackage{pith}
\pithnumber{WC25VHXO2UJZSSQTFG7O2LAVSN}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

The central empirical claim is that control-value reduction predicts translational success better than Hallmark annotation or static biomarker reversal.

C2weakest assumption

The assumption that a five-dimensional ODE model with analytic Lie-bracket derivation sufficiently captures the essential dynamics of biological controllability and that control costs can be meaningfully defined and compared across interventions without post-hoc fitting to the same success data being predicted.

C3one line summary

A control-theoretic framework is introduced in which aging is modeled as loss of safe controllability, biological age is defined as minimum control cost, and interventions are ranked by expected cost reduction using a five-dimensional ODE model and Lie-bracket analysis.

References

64 extracted · 64 resolved · 0 Pith anchors

[1] P. B. Medawar.An Unsolved Problem of Biology. H. K. Lewis, London, 1952 1952

[2] G. C. Williams. Pleiotropy, natural selection, and the evolution of senescence. Evolution, 11:398–411, 1957 1957

[3] W. D. Hamilton. The moulding of senescence by natural selection.Journal of Theoretical Biology, 12:12–45, 1966 1966

[4] D. Harman. Aging: a theory based on free radical and radiation chemistry.Journal of Gerontology, 11:298–300, 1956 1956

[5] T. B. L. Kirkwood. Evolution of ageing.Nature, 270:301–304, 1977 1977

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-20T00:03:21.656577Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

b0b5da9eeed513994a1329beed2c15934150f6a8e988f4e6e96e035e863988ec

Aliases

arxiv: 2605.16781 · arxiv_version: 2605.16781v1 · doi: 10.48550/arxiv.2605.16781 · pith_short_12: WC25VHXO2UJZ · pith_short_16: WC25VHXO2UJZSSQT · pith_short_8: WC25VHXO

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/WC25VHXO2UJZSSQTFG7O2LAVSN \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: b0b5da9eeed513994a1329beed2c15934150f6a8e988f4e6e96e035e863988ec

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "60c61f0e7369dbee309d79b1b183cecac20a3ba58ac4f7ca919926cda0cb28fa",
    "cross_cats_sorted": [
      "q-bio.PE"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "q-bio.MN",
    "submitted_at": "2026-05-16T03:23:23Z",
    "title_canon_sha256": "ac059be9295824e9dd8716f64ac91d47b699e387af11900475d692ea466120c5"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.16781",
    "kind": "arxiv",
    "version": 1
  }
}