Pith Number

pith:ZS5DTGOA

pith:2026:ZS5DTGOAKVI2UO3OFOSAEYJ3YF

not attested not anchored not stored refs pending

Learning Stable Predictors from Weak Supervision under Distribution Shift

Elias Hossain, Ivan Garibay, Mehrdad Shoeibi, Niloofar Yousefi

Weak supervision under temporal shifts leads to negative R² in CRISPR perturbation models.

arxiv:2604.05002 v3 · 2026-04-05 · cs.LG · cs.AI

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\pithnumber{ZS5DTGOAKVI2UO3OFOSAEYJ3YF}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

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The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

temporal transfer collapses across all model classes considered, yielding negative R² and weak or near-zero ρ (ridge R² = -0.145, ρ = 0.008; XGBoost R² = -0.155, ρ = 0.056; random forest R² = -0.322, ρ = 0.139)

C2weakest assumption

that reusing a fixed weak-label construction across contexts successfully isolates supervision drift rather than introducing other unmeasured changes in the data-generating process

C3one line summary

Weak supervision supports in-domain learning for CRISPR transcriptomic perturbations but temporal shifts cause negative R-squared and near-zero correlation across linear and tree models, unlike partial cell-line transfer.

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-20T02:05:42.968265Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

ccba3999c05551aa3b6e2ba402613bc16c751842a91967e26c05ef9d102dd6e5

Aliases

arxiv: 2604.05002 · arxiv_version: 2604.05002v3 · doi: 10.48550/arxiv.2604.05002 · pith_short_12: ZS5DTGOAKVI2 · pith_short_16: ZS5DTGOAKVI2UO3O · pith_short_8: ZS5DTGOA

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/ZS5DTGOAKVI2UO3OFOSAEYJ3YF \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: ccba3999c05551aa3b6e2ba402613bc16c751842a91967e26c05ef9d102dd6e5

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "b3bc20a705016052e98644f5e6d371d5fff9b7f0d51aa785c73208b990b1c483",
    "cross_cats_sorted": [
      "cs.AI"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cs.LG",
    "submitted_at": "2026-04-05T23:46:49Z",
    "title_canon_sha256": "232c9a42bac7d400e0f8217fa6047044edd85eeca45bf05e69e5dc815cb4b910"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2604.05002",
    "kind": "arxiv",
    "version": 3
  }
}