A hybrid PDE-agent model shows that tumor blood vessels shield resistant cells and that early, frequent mutations plus high proliferation reinforce drug resistance, explaining conflicting T790M findings.
Integrating models to quantify environment- mediated drug resistance
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A hybrid PDE-ABM model for angiogenesis and tumour microenvironment with application to resistance in cancer treatment
A hybrid PDE-agent model shows that tumor blood vessels shield resistant cells and that early, frequent mutations plus high proliferation reinforce drug resistance, explaining conflicting T790M findings.