Derives exact operating characteristic corrections and a numerical search over sample sizes to obtain optimal two-stage Bayes factor designs for two-arm binary-endpoint phase II trials that minimize expected sample size under the null.
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CA-BED uses Bayesian experimental design and simulated conversation trees with LLM likelihoods to optimize multi-turn question selection, reporting 21.8% higher success rates than direct prompting on entity-deduction benchmarks.
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Optimal sequential two-stage Bayes Factor Design for two-arm clinical Phase II Trials with binary Endpoints
Derives exact operating characteristic corrections and a numerical search over sample sizes to obtain optimal two-stage Bayes factor designs for two-arm binary-endpoint phase II trials that minimize expected sample size under the null.