A-CODE presents a fully atomic one-stage multimodal diffusion model for protein co-design that claims superior unconditional generation performance over prior one- and two-stage models plus a tenfold success-rate gain on hard binder-design tasks.
Fast protein backbone generation with se (3) flow matching
10 Pith papers cite this work. Polarity classification is still indexing.
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Proposes diffeomorphic optimization for manifold-constrained problems in generative models via flow maps, with Lie-group extensions for protein design showing metric improvements.
OGPP is a particle flow-matching method using orbit-space canonicalization and geometric paths that achieves lower error and fewer steps than prior approaches on 3D benchmarks.
DeCAF distills all-atom cofolding diffusion models into few-step flow maps, showing improved or matched accuracy on protein-ligand tasks with 5x fewer inference steps.
ProHiFlo introduces hierarchical coarse-to-fine flow matching with functional guidance from pretrained predictors and an adaptive SE(3)-equivariant architecture, reporting higher success rates and fewer sampling steps than prior methods on protein generation tasks.
Approximates manifold heat kernels via PINNs solving the heat equation to enable diffusion models on arbitrary manifolds including S2, SO(3), and SPD(n).
PAR is a multi-scale autoregressive transformer framework for protein backbone generation that uses coarse-to-fine prediction, noisy context learning, and flow-based decoding to achieve high-quality unconditional and zero-shot conditional outputs.
D-Flow applies multi-modality flow matching and a mirror-image data augmentation to generate D-peptides with 10.2% higher sequence identity and 24.31% top affinity on the PepMerge benchmark.
OMNI-PoseX presents a unified vision model using open-vocabulary perception and SO(3)-aware reflected flow matching to deliver state-of-the-art 6D pose estimation with real-time performance for embodied tasks.
Flow Matching is a generative modeling framework with mathematical foundations, design choices, extensions, and open-source PyTorch code for applications like image and text generation.
citing papers explorer
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A-CODE: Fully Atomic Protein Co-Design with Unified Multimodal Diffusion
A-CODE presents a fully atomic one-stage multimodal diffusion model for protein co-design that claims superior unconditional generation performance over prior one- and two-stage models plus a tenfold success-rate gain on hard binder-design tasks.
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Diffeomorphic Optimization
Proposes diffeomorphic optimization for manifold-constrained problems in generative models via flow maps, with Lie-group extensions for protein design showing metric improvements.
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Generative Modeling with Orbit-Space Particle Flow Matching
OGPP is a particle flow-matching method using orbit-space canonicalization and geometric paths that achieves lower error and fewer steps than prior approaches on 3D benchmarks.
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Few-step Cofolding with All-Atom Flow Maps
DeCAF distills all-atom cofolding diffusion models into few-step flow maps, showing improved or matched accuracy on protein-ligand tasks with 5x fewer inference steps.
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ProHiFlo: Hierarchical Flow Matching with Functional Guidance for De Novo Protein Generation
ProHiFlo introduces hierarchical coarse-to-fine flow matching with functional guidance from pretrained predictors and an adaptive SE(3)-equivariant architecture, reporting higher success rates and fewer sampling steps than prior methods on protein generation tasks.
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Riemannian Diffusion Models on General Manifolds via Physics-Informed Neural Networks
Approximates manifold heat kernels via PINNs solving the heat equation to enable diffusion models on arbitrary manifolds including S2, SO(3), and SPD(n).
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Protein Autoregressive Modeling via Multiscale Structure Generation
PAR is a multi-scale autoregressive transformer framework for protein backbone generation that uses coarse-to-fine prediction, noisy context learning, and flow-based decoding to achieve high-quality unconditional and zero-shot conditional outputs.
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D-Flow: Multi-modality Flow Matching for D-peptide Design
D-Flow applies multi-modality flow matching and a mirror-image data augmentation to generate D-peptides with 10.2% higher sequence identity and 24.31% top affinity on the PepMerge benchmark.
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OMNI-PoseX: A Fast Vision Model for 6D Object Pose Estimation in Embodied Tasks
OMNI-PoseX presents a unified vision model using open-vocabulary perception and SO(3)-aware reflected flow matching to deliver state-of-the-art 6D pose estimation with real-time performance for embodied tasks.
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Flow Matching Guide and Code
Flow Matching is a generative modeling framework with mathematical foundations, design choices, extensions, and open-source PyTorch code for applications like image and text generation.