A delay integro-differential equation model fitted to pharmacokinetic and RNA-seq data indicates that a single medium-to-high dose of pembrolizumab may suffice for effective neoadjuvant eradication of locally advanced MSI-H/dMMR colorectal tumors.
Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager
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Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
A delay integro-differential equation model fitted to pharmacokinetic and RNA-seq data indicates that a single medium-to-high dose of pembrolizumab may suffice for effective neoadjuvant eradication of locally advanced MSI-H/dMMR colorectal tumors.