Event-centric waveform foundation models are learned via self-supervised consistency on latent event structures and interactions, yielding improved performance and label efficiency over sequence-based baselines on physiological tasks.
Context clues: Evaluating long context models for clinical prediction tasks on ehrs
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TrajOnco uses a chain-of-agents LLM architecture with memory to perform temporal reasoning on longitudinal EHR, achieving 0.64-0.80 AUROC for 1-year multi-cancer risk prediction in zero-shot mode on matched cohorts while matching supervised ML on lung cancer and outperforming single-agent baselines.
The work introduces uncertainty-aware foundation models for clinical data by learning set-valued patient representations that enforce consistency across partial observations and integrate multimodal self-supervised objectives.
EHR-RAGp is a retrieval-augmented EHR foundation model that employs prototype-guided retrieval to dynamically integrate relevant historical patient context, outperforming prior models on clinical prediction tasks.
WISTERIA learns robust clinical representations from noisy EHR labels by enforcing consistency across multiple weak supervision views plus ontology regularization.
Autoregressive transformer modeling with missingness-aware contrastive pre-training outperforms baselines on MIMIC-IV and eICU benchmarks and mitigates divergent behavior from removed modalities in clinical trajectories.
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TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection
TrajOnco uses a chain-of-agents LLM architecture with memory to perform temporal reasoning on longitudinal EHR, achieving 0.64-0.80 AUROC for 1-year multi-cancer risk prediction in zero-shot mode on matched cohorts while matching supervised ML on lung cancer and outperforming single-agent baselines.
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EHR-RAGp: Retrieval-Augmented Prototype-Guided Foundation Model for Electronic Health Records
EHR-RAGp is a retrieval-augmented EHR foundation model that employs prototype-guided retrieval to dynamically integrate relevant historical patient context, outperforming prior models on clinical prediction tasks.