A framework for directly optimizing proton treatment plans using an extended probability of lesion origin (POLO) model in low-grade glioma patients.
Late Contrast Enhancing Brain Lesions in Proton-Treated Patients With Low-Grade Glioma: Clinical Evidence for Increased Periventricular Sensitivity and Variable RBE
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Voxel-level logistic regression on combined photon-proton data yields a variable proton RBE of 1 + 0.10 * LETd and identifies elevated periventricular radiosensitivity as predictors of radiation-induced brain changes.
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Direct optimization of the probability of lesion origin in proton treatment planning for low-grade glioma patients
A framework for directly optimizing proton treatment plans using an extended probability of lesion origin (POLO) model in low-grade glioma patients.
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Combined photon-proton modeling of radiation-induced brain imaging changes supports variability in proton relative biological effectiveness and increased periventricular radiosensitivity
Voxel-level logistic regression on combined photon-proton data yields a variable proton RBE of 1 + 0.10 * LETd and identifies elevated periventricular radiosensitivity as predictors of radiation-induced brain changes.