The paper predicts that treatment success in heterogeneous cell populations is controlled by the ratio of the expected population size to its fluctuation, and that slow-remission treatments have durations scaling as a power of the initial population size.
On a class of birth-death processes with time-varying intensity functions
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Efficient treatment of heterogeneous malignant cell populations
The paper predicts that treatment success in heterogeneous cell populations is controlled by the ratio of the expected population size to its fluctuation, and that slow-remission treatments have durations scaling as a power of the initial population size.