A delay integro-differential equation model fitted to pharmacokinetic and RNA-seq data indicates that a single medium-to-high dose of pembrolizumab may suffice for effective neoadjuvant eradication of locally advanced MSI-H/dMMR colorectal tumors.
Semimechanistically Based Modeling of Pembrolizumab Time-Varying Clearance Using 4 Longitudinal Covariates in Patients With Non–Small Cell Lung Cancer
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Sensitivity analysis using FAST and EFAST reduces a data-driven model of pembrolizumab therapy in de novo metastatic MSI-H/dMMR CRC to two simpler versions that reproduce original trajectories.
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Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
A delay integro-differential equation model fitted to pharmacokinetic and RNA-seq data indicates that a single medium-to-high dose of pembrolizumab may suffice for effective neoadjuvant eradication of locally advanced MSI-H/dMMR colorectal tumors.