Unsupervised rewards combining model uncertainty and semantic consistency allow protein language models to self-steer via SRO and BRO algorithms, outperforming DPO and KTO on out-of-distribution prompts while approaching oracle performance.
Sadit: Efficient protein backbone design via latent structural tokenization and diffusion transformers.arXiv preprint arXiv:2602.06706, 2026
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Be Your Own Teacher: Steering Protein Language Models via Unsupervised Reward Optimization
Unsupervised rewards combining model uncertainty and semantic consistency allow protein language models to self-steer via SRO and BRO algorithms, outperforming DPO and KTO on out-of-distribution prompts while approaching oracle performance.