PerturbedVAE disentangles perturbation-specific signals from invariant gene expression structure to recover causal representations and improve out-of-distribution prediction in single-cell perturbation modeling.
Nature methods , volume=
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The paper defines possibility space, timing computation, and causal factum to make timing a computable variable, and illustrates the framework with automatic trajectory discovery and counterfactual timing on 3,276 breast-cancer patients.
AblateCell reproduces baselines in three single-cell perturbation repositories with 88.9% success and recovers ground-truth critical components with 93.3% accuracy via closed-loop ablation.
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To Use AI as Dice of Possibilities with Timing Computation
The paper defines possibility space, timing computation, and causal factum to make timing a computable variable, and illustrates the framework with automatic trajectory discovery and counterfactual timing on 3,276 breast-cancer patients.
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AblateCell: A Reproduce-then-Ablate Agent for Virtual Cell Repositories
AblateCell reproduces baselines in three single-cell perturbation repositories with 88.9% success and recovers ground-truth critical components with 93.3% accuracy via closed-loop ablation.