The paper introduces a protocol-resolved framework for virological measurements, defining an observation operator that maps latent ensembles to observed data and recasting plaque assays as estimates of protocol-conditioned infectious concentration.
Eliminating effects of particle adsorp- tion to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO,
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Experimental Collapse in Virophysics: Protocol-Resolved Observation, Inference, and Plaque-Assay Blindness
The paper introduces a protocol-resolved framework for virological measurements, defining an observation operator that maps latent ensembles to observed data and recasting plaque assays as estimates of protocol-conditioned infectious concentration.