AffinityFlow guides AlphaFlow structure generation toward low Rosetta binding energy, then inverse-folds the structures to propose antibody mutations, and reports top scores on a computational affinity maturation benchmark.
F., Leaver-Fay, A., Jeliazkov, J
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AffinityFlow: Guided Flows for Antibody Affinity Maturation
AffinityFlow guides AlphaFlow structure generation toward low Rosetta binding energy, then inverse-folds the structures to propose antibody mutations, and reports top scores on a computational affinity maturation benchmark.