SILO outperforms five baselines on eight protein fitness landscapes by using trajectory-level imitation on trajectories selected via hierarchical beam search and biological proxy guidance under limited oracle budgets.
Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme.Proceedings of the National Academy of Sciences, 87(2): 696–700, January 1990
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Self-Improvement Imitation with Biologically Guided Search for Protein Design Under Oracle Budgets
SILO outperforms five baselines on eight protein fitness landscapes by using trajectory-level imitation on trajectories selected via hierarchical beam search and biological proxy guidance under limited oracle budgets.