GoForth is a forward-trained encoder-decoder RNA language model that generates sequences under mixed constraints on fold, sequence, and coding by separating sequence prior, forward folding sampler, and reward oracle.
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This review surveys current machine learning methods for RNA secondary structure prediction, identifies a generalization crisis prompting homology-aware benchmarking, and outlines future challenges including pseudoknots, long transcripts, modified nucleotides, and dynamic ensembles.
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GoForth: Language Models for RNA Design under Structure, Sequence, and Coding Constraints
GoForth is a forward-trained encoder-decoder RNA language model that generates sequences under mixed constraints on fold, sequence, and coding by separating sequence prior, forward folding sampler, and reward oracle.
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Machine Learning for RNA Secondary Structure Prediction: a review of current methods and challenges
This review surveys current machine learning methods for RNA secondary structure prediction, identifies a generalization crisis prompting homology-aware benchmarking, and outlines future challenges including pseudoknots, long transcripts, modified nucleotides, and dynamic ensembles.