Drug-blind cancer sensitivity prediction is limited by evaluation metric and training distribution rather than drug representation complexity.
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles.Cell, 171(6): 1437–1452.e17
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CellScientist introduces a dual-space hierarchical orchestration system that enables closed-loop refinement of virtual cell models by routing execution discrepancies back to hypothesis or implementation updates, yielding improved benchmark performance with auditable traces.
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Training distribution determines the ceiling of drug-blind cancer sensitivity prediction
Drug-blind cancer sensitivity prediction is limited by evaluation metric and training distribution rather than drug representation complexity.
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CellScientist: Dual-Space Hierarchical Orchestration for Closed-Loop Refinement of Virtual Cell Models
CellScientist introduces a dual-space hierarchical orchestration system that enables closed-loop refinement of virtual cell models by routing execution discrepancies back to hypothesis or implementation updates, yielding improved benchmark performance with auditable traces.