A two-type ecDNA model shows switching does not alter total copy number distribution under equal fitness, but allows mixed cells to persist.
Targeted therapy resistance medi- ated by dynamic regulation of extrachromosomal mutant EGFR DNA.Science, 343:72–76, 2014
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Population dynamics of multiple ecDNA types
A two-type ecDNA model shows switching does not alter total copy number distribution under equal fitness, but allows mixed cells to persist.