Slow, nonadiabatic chromatin-state transitions generate circular probability currents, hysteresis, and an entropy-production peak that can tune gene-expression fluctuations, explaining the large Nanog heterogeneity in mouse embryonic stem cells.
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Landscapes and nonequilibrium fluctuations of eukaryotic gene regulation
Slow, nonadiabatic chromatin-state transitions generate circular probability currents, hysteresis, and an entropy-production peak that can tune gene-expression fluctuations, explaining the large Nanog heterogeneity in mouse embryonic stem cells.