A held-out particle set and BioEM posterior calculations can distinguish overfitted cryo-EM reconstructions from well-behaved ones by checking whether map probability grows with added high-frequency detail.
Single-Particle Cryo-EM at Crystallographic Resolution
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Cross-validation tests for cryo-EM maps using an independent particle set
A held-out particle set and BioEM posterior calculations can distinguish overfitted cryo-EM reconstructions from well-behaved ones by checking whether map probability grows with added high-frequency detail.