FLASH radiotherapy's normal-tissue sparing appears only at intermediate baseline oxygen levels; measured oxygen consumption is too small to explain it by transient hypoxia.
OH radicals from the indirect actions of X-rays induce cell lethality and mediate the majority of the oxygen enhancement effect
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Review of oxygen measurement and relevance to the mechanisms of FLASH radiotherapy
FLASH radiotherapy's normal-tissue sparing appears only at intermediate baseline oxygen levels; measured oxygen consumption is too small to explain it by transient hypoxia.