Stochastic models predict remodeler competition reduces nucleosome detachment times when binding affinities match histone-DNA contacts, motors yield detachment rates proportional to bond dissociation constant times motor speed, and multimeric kinetics allow histone concentrations to rescue partials.
Nucleosome breathing facilitates cooperative binding of pluripotency factors Sox2 and Oct4 to DNA
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Stochastic nucleosome disassembly mediated by remodelers and histone fragmentation
Stochastic models predict remodeler competition reduces nucleosome detachment times when binding affinities match histone-DNA contacts, motors yield detachment rates proportional to bond dissociation constant times motor speed, and multimeric kinetics allow histone concentrations to rescue partials.