A parametric linear regression model for quantile functions, applied to CT lung-density data, estimates treatment response with explicit confidence intervals.
Scalable Function-on-Scalar Quantile Regression for Densely Sampled Functional Data
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abstract
Functional quantile regression (FQR) is a useful alternative to mean regression for functional data as it provides a comprehensive understanding of how scalar predictors influence the conditional distribution of functional responses. In this article, we study the FQR model for densely sampled, high-dimensional functional data without relying on parametric error or independent stochastic process assumptions, with the focus on statistical inference under this challenging regime along with scalable implementation. This is achieved by a simple but powerful distributed strategy, in which we first perform separate quantile regression to compute $M$-estimators at each sampling location, and then carry out estimation and inference for the entire coefficient functions by properly exploiting the uncertainty quantification and dependence structure of $M$-estimators. We derive a uniform Bahadur representation and a strong Gaussian approximation result for the $M$-estimators on the discrete sampling grid, leading to dimension reduction and serving as the basis for inference. An interpolation-based estimator with minimax optimality is proposed, and large sample properties for point and simultaneous interval estimators are established. The obtained minimax optimal rate under the FQR model shows an interesting phase transition phenomenon that has been previously observed in functional mean regression. The proposed methods are illustrated via simulations and an application to a mass spectrometry proteomics dataset.
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A linear regression model for quantile function data applied to paired pulmonary 3d CT scans
A parametric linear regression model for quantile functions, applied to CT lung-density data, estimates treatment response with explicit confidence intervals.