The KaiABC circuit oscillates only in a narrow concentration range; minimizing free-energy cost for a given precision produces a ~21-hour period that entrains to 24 hours when external forcing exceeds ~10% of the metabolic rate.
Sasai, Role of the reaction-structure coupling in tem- perature compensation of the KaiABC circadian rhythm, PLOS Computational Biology 18, e1010494 (2022)
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Physical Constraints on the Rhythmicity of the Biological Clock
The KaiABC circuit oscillates only in a narrow concentration range; minimizing free-energy cost for a given precision produces a ~21-hour period that entrains to 24 hours when external forcing exceeds ~10% of the metabolic rate.