Contrastive metric learning on TCR co-specificity data yields a distance metric that generalizes to unseen pMHCs and highlights steric over hydrophobic amino-acid properties.
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Data-driven Discovery of Biophysical T Cell Receptor Co-specificity Rules
Contrastive metric learning on TCR co-specificity data yields a distance metric that generalizes to unseen pMHCs and highlights steric over hydrophobic amino-acid properties.