Mean first-passage time sensitivities of any finite Markov chain lie in [-1,1] and sum to -1, a conserved control budget that caps kinetic-proofreading discrimination at the number of checkpoints.
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A Universal Control Budget for First-Passage Kinetics
Mean first-passage time sensitivities of any finite Markov chain lie in [-1,1] and sum to -1, a conserved control budget that caps kinetic-proofreading discrimination at the number of checkpoints.