A new algorithm simulates exact trajectories of bursty PDMP models for arbitrary interacting genes at lower cost than SSA, with a toggle-switch example showing bimodal expression arises from interaction-driven burst frequencies rather than bursting alone.
Incorporating spatial diffusion into models of bursty stochastic transcription
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Trajectory data resolves structural non-identifiability in lattice random walk diffusion models that count data alone cannot, with analysis of experimental design impacts on practical identifiability.
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Efficient stochastic simulation of gene regulatory networks using hybrid models of transcriptional bursting
A new algorithm simulates exact trajectories of bursty PDMP models for arbitrary interacting genes at lower cost than SSA, with a toggle-switch example showing bimodal expression arises from interaction-driven burst frequencies rather than bursting alone.
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When do trajectories matter? Identifiability analysis for stochastic transport phenomena
Trajectory data resolves structural non-identifiability in lattice random walk diffusion models that count data alone cannot, with analysis of experimental design impacts on practical identifiability.