Structural identifiability analysis shows point sources restore identifiability for inferring spatial stochastic dynamics parameters from static snapshots, unlike distributed sources, with limits depending on modeling choices.
Incorporating spatial diffusion into models of bursty stochastic transcription
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A new algorithm simulates exact trajectories of bursty PDMP models for arbitrary interacting genes at lower cost than SSA, with a toggle-switch example showing bimodal expression arises from interaction-driven burst frequencies rather than bursting alone.
Trajectory data resolves structural non-identifiability in lattice random walk diffusion models that count data alone cannot, with analysis of experimental design impacts on practical identifiability.
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Efficient stochastic simulation of gene regulatory networks using hybrid models of transcriptional bursting
A new algorithm simulates exact trajectories of bursty PDMP models for arbitrary interacting genes at lower cost than SSA, with a toggle-switch example showing bimodal expression arises from interaction-driven burst frequencies rather than bursting alone.