The paper introduces a protocol-resolved framework for virological measurements, defining an observation operator that maps latent ensembles to observed data and recasting plaque assays as estimates of protocol-conditioned infectious concentration.
Correction: Time to revisit the endpoint dilution assay and to replace the TCID50 as a measure of a virus sample’s infection concentration,
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Experimental Collapse in Virophysics: Protocol-Resolved Observation, Inference, and Plaque-Assay Blindness
The paper introduces a protocol-resolved framework for virological measurements, defining an observation operator that maps latent ensembles to observed data and recasting plaque assays as estimates of protocol-conditioned infectious concentration.