Biological ambiguity from temporally decoupled neurodegeneration and amyloid pathology creates one-to-many mappings that make MRI-to-amyloid PET synthesis intrinsically ill-posed, with performance restored by multimodal inputs.
Annals of Neurology72, 578–586 (10 2012)
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When Brains Disagree: Biological Ambiguity Underlies the Challenge of Amyloid PET Synthesis from Structural MRI
Biological ambiguity from temporally decoupled neurodegeneration and amyloid pathology creates one-to-many mappings that make MRI-to-amyloid PET synthesis intrinsically ill-posed, with performance restored by multimodal inputs.