15N enrichment raises alpha-induced DSB++ by 175% and carbon-induced by 53% in simulations, while 15N-glutamine treatment yields 15% more cell death after 2 Gy irradiation with no added cytotoxicity.
NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy
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Voxel-level logistic regression on combined photon-proton data yields a variable proton RBE of 1 + 0.10 * LETd and identifies elevated periventricular radiosensitivity as predictors of radiation-induced brain changes.
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Simulation of complex DNA damage enhancement and biological effect validation for Proton-CAT
15N enrichment raises alpha-induced DSB++ by 175% and carbon-induced by 53% in simulations, while 15N-glutamine treatment yields 15% more cell death after 2 Gy irradiation with no added cytotoxicity.
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Combined photon-proton modeling of radiation-induced brain imaging changes supports variability in proton relative biological effectiveness and increased periventricular radiosensitivity
Voxel-level logistic regression on combined photon-proton data yields a variable proton RBE of 1 + 0.10 * LETd and identifies elevated periventricular radiosensitivity as predictors of radiation-induced brain changes.