Under controlled simulations and two real datasets, ComBAT harmonization fails when sites differ in age slope, have under 16 to 32 subjects, narrow age ranges, or mix pathological cases into parameter estimation.
Multi-Site Harmonization of Dif- fusion MRI Data via Method of Moments
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ComBAT Harmonization for diffusion MRI: Challenges and Best Practices
Under controlled simulations and two real datasets, ComBAT harmonization fails when sites differ in age slope, have under 16 to 32 subjects, narrow age ranges, or mix pathological cases into parameter estimation.