mRNAutilus generates full-length therapeutic mRNAs via diffusion models and multi-objective guidance, achieving over 400-fold expression gains for luciferase and outperforming baselines for Spike and other targets in zero-shot tests.
Tr2-d2: Tree search guided trajectory-aware fine-tuning for discrete diffusion.arXiv preprint arXiv:2509.25171, 2025
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GeoCycler aligns latent diffusion models via reward-weighted training with a type-gated stair reward to raise cyclic peptide closure rates across multiple topologies on the LNR benchmark.
RAVEN aligns training and inference for causal autoregressive video diffusion via interleaved rollout repacking and introduces CM-GRPO for direct RL on consistency-model kernels, claiming better quality than recent baselines.
citing papers explorer
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mRNAutilus: Multi-Objective-Guided Discrete Generation of mRNA with Optimized Therapeutic Properties
mRNAutilus generates full-length therapeutic mRNAs via diffusion models and multi-objective guidance, achieving over 400-fold expression gains for luciferase and outperforming baselines for Spike and other targets in zero-shot tests.
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GeoCycler: Reward-Aligned 3D Diffusion for Constraint-Conditioned Cyclic Peptide Design
GeoCycler aligns latent diffusion models via reward-weighted training with a type-gated stair reward to raise cyclic peptide closure rates across multiple topologies on the LNR benchmark.
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RAVEN: Real-time Autoregressive Video Extrapolation with Consistency-model GRPO
RAVEN aligns training and inference for causal autoregressive video diffusion via interleaved rollout repacking and introduces CM-GRPO for direct RL on consistency-model kernels, claiming better quality than recent baselines.