A hydrodynamic framework shows contractile cross-linker stresses cause mechanically driven heterochromatin phase separation into droplets that wet the nuclear boundary, while active transcription fluctuations drive long-range coherent chromatin motions and deform the droplets.
(C1) and (C2), and a perturbation in the nematic order parameter, Q= ¯Q+ε δQ(r, t),(C18) about a homogeneous state ¯Q, whereδQare the corre- sponding linear perturbations
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Active Hydrodynamic Theory of Euchromatin and Heterochromatin
A hydrodynamic framework shows contractile cross-linker stresses cause mechanically driven heterochromatin phase separation into droplets that wet the nuclear boundary, while active transcription fluctuations drive long-range coherent chromatin motions and deform the droplets.