Energy-based sampling with a human-antibody prior generates diverse heavy-chain mutants near the wild type that lie on predicted affinity-solubility Pareto fronts and outperform constrained local search in synthetic benchmarks.
(2022) Improving antibody affinity through in vitro mutagenesis in complementarity determining re- gions
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Energy-based generative models for monoclonal antibodies
Energy-based sampling with a human-antibody prior generates diverse heavy-chain mutants near the wild type that lie on predicted affinity-solubility Pareto fronts and outperform constrained local search in synthetic benchmarks.