A conditional genotype-based association test that conditions the Pearson chi-square statistic on the HWE chi-square in controls, with asymptotic theory and simulations showing higher power than competing methods.
Genome-wide association study of 14,000 cases of seven common dis- eases and 3,000 shared controls.Nature2007;447(7145):661–678
2 Pith papers cite this work. Polarity classification is still indexing.
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The paper argues that statistical inference requires nuanced scientific context and that universal significance thresholds should be abandoned.
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Evaluating HWE and Association in Genome Wide Association Studies: A Unified Procedure
A conditional genotype-based association test that conditions the Pearson chi-square statistic on the HWE chi-square in controls, with asymptotic theory and simulations showing higher power than competing methods.
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Applied Statistics Requires Scientific Context
The paper argues that statistical inference requires nuanced scientific context and that universal significance thresholds should be abandoned.