Stochastic models predict remodeler competition reduces nucleosome detachment times when binding affinities match histone-DNA contacts, motors yield detachment rates proportional to bond dissociation constant times motor speed, and multimeric kinetics allow histone concentrations to rescue partials.
Why do nucleosomes unwrap asymmetrically? The Journal of Physical Chemistry B , 120(26):5855--5863, 2016
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Stochastic nucleosome disassembly mediated by remodelers and histone fragmentation
Stochastic models predict remodeler competition reduces nucleosome detachment times when binding affinities match histone-DNA contacts, motors yield detachment rates proportional to bond dissociation constant times motor speed, and multimeric kinetics allow histone concentrations to rescue partials.