A hybrid PDE-agent model shows that tumor blood vessels shield resistant cells and that early, frequent mutations plus high proliferation reinforce drug resistance, explaining conflicting T790M findings.
Multiscale modeling of drug resistance in glioblastoma with gene mutations and angiogenesis
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
citation-role summary
background 1
citation-polarity summary
fields
math.NA 1years
2025 1verdicts
CONDITIONAL 1roles
background 1polarities
background 1representative citing papers
citing papers explorer
-
A hybrid PDE-ABM model for angiogenesis and tumour microenvironment with application to resistance in cancer treatment
A hybrid PDE-agent model shows that tumor blood vessels shield resistant cells and that early, frequent mutations plus high proliferation reinforce drug resistance, explaining conflicting T790M findings.