Correlators of chiral primaries and 1/8 BPS Wilson loops from perturbation theory

We study at perturbative level the correlation functions of a general class of 1/8 BPS Wilson loops and chiral primaries in N = 4 Super Yang-Mills theory. The contours and the location of operator insertions share a sphere S^2 embedded into spacetime and the system preserves at least two supercharges. We perform explicit two-loop computations, for some particular but still rather general configuration, that confirm the elegant results expected from localization procedure. We find notably full consistency with the multi-matrix model averages, obtained from 2D Yang-Mills theory on the sphere, when interacting diagrams do not cancel and contribute non-trivially to the final answer.