Is absolute separability determined by the partial transpose?

The absolute separability problem asks for a characterization of the quantum states $\rho \in M_m\otimes M_n$ with the property that $U\rho U^\dagger$ is separable for all unitary matrices $U$. We investigate whether or not it is the case that $\rho$ is absolutely separable if and only if $U\rho U^\dagger$ has positive partial transpose for all unitary matrices $U$. In particular, we develop an easy-to-use method for showing that an entanglement witness or positive map is unable to detect entanglement in any such state, and we apply our method to many well-known separability criteria, including the range criterion, the realignment criterion, the Choi map and its generalizations, and the Breuer-Hall map. We also show that these two properties coincide for the family of isotropic states, and several eigenvalue results for entanglement witnesses are proved along the way that are of independent interest.