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arxiv: 2504.05496 · v1 · pith:LAMHOLEJnew · submitted 2025-04-07 · 💻 cs.CL

A Survey on Hypothesis Generation for Scientific Discovery in the Era of Large Language Models

Atilla Kaan Alkan , Shashwat Sourav , Maja Jablonska , Simone Astarita , Rishabh Chakrabarty , Nikhil Garuda , Pranav Khetarpal , Maciej Pi\'oro
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Dimitrios Tanoglidis Kartheik G. Iyer Mugdha S. Polimera Michael J. Smith Tirthankar Ghosal Marc Huertas-Company Sandor Kruk Kevin Schawinski Ioana Ciuc\u{a}
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classification 💻 cs.CL
keywords hypothesisgenerationllmssurveydiscoverylanguagelargemodels
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Hypothesis generation is a fundamental step in scientific discovery, yet it is increasingly challenged by information overload and disciplinary fragmentation. Recent advances in Large Language Models (LLMs) have sparked growing interest in their potential to enhance and automate this process. This paper presents a comprehensive survey of hypothesis generation with LLMs by (i) reviewing existing methods, from simple prompting techniques to more complex frameworks, and proposing a taxonomy that categorizes these approaches; (ii) analyzing techniques for improving hypothesis quality, such as novelty boosting and structured reasoning; (iii) providing an overview of evaluation strategies; and (iv) discussing key challenges and future directions, including multimodal integration and human-AI collaboration. Our survey aims to serve as a reference for researchers exploring LLMs for hypothesis generation.

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