Cooperativity of Protein Folding and the Random-Field Ising Model

A. M. Gutin; Cambridge; Department of Chemistry; E. I. Shakhnovich (Harvard University; MA); V. I. Abkevich

arxiv: cond-mat/9606136 · v1 · submitted 1996-06-18 · ❄️ cond-mat · q-bio

Cooperativity of Protein Folding and the Random-Field Ising Model

A. M. Gutin , V. I. Abkevich , E. I. Shakhnovich (Harvard University , Department of Chemistry , Cambridge , MA) This is my paper

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keywords foldingmodelcooperativecooperativityheterogeneityisingproteinrandom-field

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The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding transition for small heterogeneity of the interactions stabilizing the native structure. Monte Carlo simulation of a lattice model shows that starting from some finite heterogeneity folding transition is not cooperative and involves formation of domains.

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Cooperativity of Protein Folding and the Random-Field Ising Model

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