Sequence sensitivity of breathing dynamics in heteropolymer DNA
classification
🧬 q-bio.BM
cond-mat.stat-mech
keywords
sequencedatadynamicsheteropolymeragreementbacteriophagebiologicalbreathing
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We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy (FCS) is demonstrated.
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